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What causes plaque in the brain? Abnormal buildup in the brain Amyloid plaques are clumps of beta-amyloid, a piece of a protein that is found in the normal brain. When these beta-amyloid proteins clump together, they form plaques that can disrupt communication between nerve cells and cause brain inflammation. What does Alzheimer's do to the brain? At first, Alzheimer's disease typically destroys neurons and their connections in parts of the brain involved in memory, including the entorhinal cortex and hippocampus. It later affects areas in the cerebral cortex responsible for language, reasoning, and social behavior. Is donepezil effective for treating Alzheimer's disease? AChE inhibitors are the only agents recommended for the treatment of cognitive decline in patients with mild to moderate Alzheimer's disease. Donepezil is more effective than placebo and is well tolerated in improving the major symptoms of this disease. How do dementia drugs work? The most prescribed include a group of drugs called cholinesterase inhibitors. These drugs do not stop the underlying progress of dementia, but they often support better thinking and memory. The drugs work by boosting a brain chemical that is essential for healthy thinking and functioning. What drugs are linked to dementia? A study published in the journal JAMA Internal Medicine on Monday suggests that the link is strongest for certain classes of anticholinergic drugs -- particularly antidepressants such as paroxetine or amitriptyline, bladder antimuscarinics such as oxybutynin or tolterodine, antipsychotics such as chlorpromazine or
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