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Does misoprostol have any side effect? Side Effects. Nausea or stomach cramps may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. What can I expect after taking the abortion pill? What to expect after the misoprostol Cramping usually starts one to four hours after you place the misoprostol in your vagina. Bleeding usually starts between 30 minutes to four hours after you place the misoprostol in your vagina. Heavy bleeding and strong cramps usually last between one and four hours. How long does misoprostol take to dissolve? Take the 4 misoprostol pills. Put 2 pills on one side of your mouth, and the other 2 on the other side of your mouth. Wait 3 minutes for the pill to dissolve. After 30 minutes, swallow what is left of the pills.
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